PTD-DBM
Characteristics
| Molecular Formula | C124H225N61O28S2 |
| CAS Number | 1609454-11-6 |
| Molar Mass | 3082.67 g/mol |
| Amino Acid Sequence | Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Gly-Arg-Lys-Thr-Gly-His-Gln-Ile-Cys-Lys-Phe-Arg-Lys-Cys |
| Synonyms | Protein Transduction Domain-fused Dishevelled Binding Motif, Protein transduction domain (PTD)-Dvl-binding motif (DBM) |
| Solubility | Water-soluble |
| Organoleptic Profile | White to off-white powder |
| Composition | Lyophilized powder – requires reconstitution |
| Form | Lyophilized powder |
| Storage | Store at -20 °C, dry and protected from light. Short-term storage at 2-8 °C is acceptable for up to 4 weeks. |
How is PTD-DBM Used in Research?
PTD-DBM peptide mechanism of action research suggests it may primarily function as a peptide inhibitor of the CXXC5-Dishevelled protein interaction, potentially activating the Wnt/beta-catenin signaling pathway. Current studies on ptd-dbm examine the compound in hair follicle renewal models through multiple potential molecular pathways.
The primary mechanism research suggests that ptd dbm peptide may involve the competitive binding to the Dishevelled (Dvl) protein, potentially preventing CXXC5 from inhibiting the Wnt/beta-catenin pathway. By disrupting this inhibitory interaction, ptd dbm may enhance downstream signaling involved in hair follicle development and renewal through both direct and indirect cellular pathways.
Additionally, studies indicate PTD-DBM may have effects on wound-induced hair neogenesis (WIHN) and tissue repair. Research has examined its relationship to follicle stem cells and keratinocyte proliferation, and to follicle-cycling endpoints.
The peptide’s protein transduction domain (PTD) structure, consisting of eight arginine residues, may allow for enhanced cellular penetration.
Research also suggests potential synergistic effects when combined with compounds like valproic acid (VPA), which may further activate the Wnt/beta-catenin pathway through GSK3beta inhibition.
For research institutions looking to buy ptd-dbm from a verified ptd-dbm peptide supplier, sourcing high-purity material with validated analytical data is critical to ensure experimental accuracy and reproducibility.
Summary
PTD-DBM is a 25-residue synthetic peptide studied for its binding to the Dishevelled (Dvl) protein, which blocks the CXXC5-Dvl interaction in Wnt/beta-catenin signalling. Published laboratory work examines it in hair-follicle and skin cell models. For laboratory research use only.
Resource
Supplied by Power Peptides within the Research Peptides category alongside related reference materials including GHK-Cu 50mg Research Atomizer System, Epithalon Research Atomizer System, and DSIP Research Atomizer System. All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
