ARA-290
Characteristics
| Molecular Formula | C51H84N16O21 |
| CAS | 1208243-50-8 |
| Molar Mass | 1257.31 g/mol |
| Chemical Formula | C51H84N16O21 |
| Amino Acid Sequence | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Synonyms | Pyroglutamate Helix B Surface Peptide, pHBSP, ARA 290, Cibinetide |
| Solubility | Water-soluble |
| Organoleptic Profile | White to off-white powder |
| Composition | Lyophilized powder – requires reconstitution |
| Form | Lyophilized powder |
| Storage | Store at -20 °C, dry and protected from light. Short-term storage at 2-8 °C is acceptable for up to 4 weeks. |
How does ARA-290 work?
ARA-290 exerts its effects by selectively activating the innate repair receptor (IRR), a heteromeric complex composed of EPO receptor (EPOR) and beta common receptor (betacR) subunits. This specific interaction triggers a cascade of signaling events that has been examined for anti-inflammatory, tissue-protective, and repair-related effects. ARA-290 has been shown to modulate the immune response by reducing the production of pro-inflammatory cytokines and increasing the expression of anti-inflammatory mediators. Additionally, it has been studied for effects on the survival and function of various cell types, including endothelial cells, cardiomyocytes, and neurons, under stress conditions.
Handling & Safety
Handle as a laboratory research chemical of unknown hazard. Use gloves and eye protection, avoid inhalation of the lyophilized powder, and follow standard laboratory handling procedures.
Reconstitute and store according to the product label. Lyophilized material should be kept cool, dry and protected from light; reconstituted material should be held at 2-8°C and protected from light.
The safety profile of ARA-290 has not been established. This compound is supplied for laboratory research use only and is not approved for human or veterinary use.
Preparation
ARA-290 Experimental Reagent: Preparation Guidelines Important: Please read these instructions carefully before handling the ARA-290 experimental reagent.
Dissolution:
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Due to the high density of ARA-290, dissolve 12mg of the reagent in a minimum of 3ml of reconstitution solution.
Preparation Steps:
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Remove the experimental reagent from storage and allow it to reach room temperature (approximately 2-3 hours).
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Once at room temperature, add the appropriate amount of reconstitution solution.
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After reconstitution, keep the solution at room temperature. Do not refrigerate or refreeze.
Caution:
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Reconstituting or storing the reagent in low-temperature environments may cause cloudiness.
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Avoid exposing the reconstituted solution to cold temperatures to maintain its clarity and activity.
For optimal results, please follow these guidelines closely.
Summary
ARA 290 peptide is a synthetic peptide that has been studied for EPO-like tissue-protective properties without stimulation of erythropoiesis. ARA-290 selectively activates the innate repair receptor and has been examined for anti-inflammatory, neuroprotective, cardioprotective, and renoprotective effects in various preclinical models. Clinical studies have also examined it in tissue-protection and wound research. With its wide-ranging research relevance, ARA-290 remains a subject of study in models of tissue damage and inflammation.
For laboratories searching for ara 290 for sale or looking to buy ara 290, sourcing from a reputable research-grade supplier with verified purity and analytical validation is essential to ensure experimental accuracy.
Resource
Supplied by Power Peptides within the Research Peptides category alongside related reference materials including Selank Research Atomizer System, TB-500, and Selank. All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
