PP-TS1 Research Compound
Characteristics
| Molecular Formula | C221H366N72O67S |
| CASNumber | 218949-48-5 |
| Molar Mass | 5135.9 g/mol |
| Amino Acid Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 |
| Synonyms | TH9507, Egrifta, Lipodystrophy Drug |
| Solubility | Water-soluble |
| Organoleptic Profile | White to off-white powder |
| Composition | Lyophilized powder – requires reconstitution |
| Form | Lyophilized powder |
| Storage | Store at -20 °C, dry and protected from light. Short-term storage at 2-8 °C is acceptable for up to 4 weeks. |
How does PP-TS1 work?
PP-TS1 is a synthetic growth hormone-releasing hormone (GHRH) analog that has been the subject of extensive research in the field of endocrinology and metabolism. This peptide’s primary mechanism of action involves binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland. This activation stimulates the synthesis and pulsatile release of endogenous growth hormone (GH), which in turn promotes the production of insulin-like growth factor-1 (IGF-1) in the liver and other tissues.
Research
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Visceral Adipose Tissue (VAT): PP-TS1 has been examined in research on GH-axis regulation of visceral adipose tissue and associated metabolic markers.
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Insulin Sensitivity: Investigations have examined the relationship between GHRH-receptor activation, the GH/IGF-1 axis and insulin sensitivity.
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Neurobiology: GHRH-receptor signalling has been examined in relation to cognitive and neurophysiological endpoints, including measures of executive function, attention, and memory.
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Body composition: Research has examined PP-TS1 in relation to lean mass measures.
Handling & Safety
Handle as a laboratory research chemical of unknown hazard. Use gloves and eye protection, avoid inhalation of the lyophilized powder, and follow standard laboratory handling procedures.
Reconstitute and store according to the product label. Lyophilized material should be kept cool, dry and protected from light; reconstituted material should be held at 2-8°C and protected from light.
The safety profile of PP-TS1 has not been established. This compound is supplied for laboratory research use only and is not approved for human or veterinary use.
Summary
PP-TS1 is a growth hormone-releasing hormone (GHRH) analog studied as a GHRH-receptor agonist. By stimulating the production and release of endogenous growth hormone (GH) from the anterior pituitary gland, PP-TS1 increases the production of insulin-like growth factor-1 (IGF-1). Published studies have measured changes in visceral adipose tissue, insulin sensitivity, cognitive endpoints, lean mass and bone markers. As a research peptide, PP-TS1 is used to investigate the interplay between GHRH-receptor signalling, the GH/IGF-1 axis and metabolism.
Resource
Supplied by Power Peptides within the Research Peptides category alongside related reference materials including Ipamorelin, NAD+, and GLP-1SM Research Compound. All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
